UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                            -------------------------

                                    FORM 8-K

                                 CURRENT REPORT
                     PURSUANT TO SECTION 13 OR 15(d) OF THE
                         SECURITIES EXCHANGE ACT OF 1934

Date of report
(Date of earliest event reported) October 20, 2005 (October 20, 2005)
                                  -----------------------------------

                         Cass Information Systems, Inc.
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             (Exact Name of Registrant as Specified in its Charter)

                                    Missouri
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                 (State or Other Jurisdiction of Incorporation)

         2-80070                                           43-1265338
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(Commission File Number)                       (IRS Employer Identification No.)

13001 Hollenberg Drive, Bridgeton, Missouri                              63044
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 (Address of Principal Executive Offices)                             (Zip Code)

                                 (314) 506-5500
- --------------------------------------------------------------------------------
              (Registrant's Telephone Number, Including Area Code)

                                       N/A
- --------------------------------------------------------------------------------
          (Former Name or Former Address, if Changed Since Last Report)

Check the appropriate box below if the Form 8-K filing is intended to
simultaneously satisfy the filing obligation of the registrant under any of the
following provisions:

|_|   Written communications pursuant to Rule 425 under the Securities Act (17
      CFR 230.425)

|_|   Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR
      240.14a-12)

|_|   Pre-commencement communications pursuant to Rule 14d-2(b) under the
      Exchange Act (17 CFR 240.14d-2(b))

|_|   Pre-commencement communications pursuant to Rule 13e-4(c) under the
      Exchange Act (17 CFR 240.13e-4(c))



                         CASS INFORMATION SYSTEMS, INC.

                                    FORM 8-K

Item 2.02. Results of Operations and Financial Condition.

      On October 20, 2005, Cass Information Systems, Inc. issued a press release
announcing its preliminary results of operations for the third quarter of fiscal
year 2005, which ended September 30, 2005. A copy of the press release is
attached hereto as Exhibit 99.1 and hereby incorporated by reference. The
information in this Form 8-K, including Exhibit 99.1, is being furnished under
Item 2.02 and shall not be deemed to be "filed" for the purposes of Section 18
of the Securities Exchange Act of 1934 (the "Exchange Act"), as amended, or
otherwise subject to the liabilities of such section, nor shall such information
be deemed incorporated by reference in any filing under the Securities Act of
1933 or the Exchange Act, as amended, except as shall be expressly set forth by
specific reference in such a filing.

Item 9.01. Financial Statements and Exhibits.

(c)   Exhibits

      Exhibit No.       Description
      -----------       -----------

         99.1           Press Release dated October 20, 2005, issued by Cass
                        Information Systems, Inc.

                                       2


                                   SIGNATURES

      Pursuant to the requirements of the Securities Exchange Act of 1934, the
registrant has duly caused this report to be signed on its behalf by the
undersigned hereunto duly authorized.

                                    Cass Information Systems, Inc.


October 20, 2005                    By:          /s/ Lawrence A. Collett
                                        ----------------------------------------
                                                     Lawrence A. Collett
                                            Chairman and Chief Executive Officer


October 20, 2005                    By:          /s/ Eric H. Brunngraber
                                        ----------------------------------------
                                                     Eric H. Brunngraber
                                                  Vice President-Secretary
                                        (Chief Financial and Accounting Officer)


                                       3


                                  EXHIBIT INDEX

      Exhibit
      Number            Description
      ------            -----------

      99.1              Press Release dated October 20, 2005, issued by Cass
                        Information Systems, Inc.


                                       4
                                  Exhibit 99.1

                                                                October 20, 2005

                      Cass Information Systems, Inc. Posts
                    57% Increase in 3rd Quarter 2005 Earnings

      Firm Continues Record-Setting Earnings Pace

      ST. LOUIS - Cass Information Systems, Inc. (NASDAQ: CASS), the nation's
leading provider of transportation, utility and telecom invoice payment and
information services, reported third quarter earnings of 55 cents per
fully-diluted share, a 57% increase from the 35 cents (adjusted for the
September 15, 2005 50% stock dividend) reported for the third quarter of 2004.

      Net income for the quarter was also up 57% to $3,093,000, compared to the
$1,973,000 reported in the third quarter of 2004. Total revenues increased 20%
or $3,234,000 over the comparable period of the preceding year.

      "The third quarter 2005 outcome means that year-to-date the company has
already achieved an all-time annual earnings record for shareholders. Presuming
a profitable fourth quarter, we will raise the bar even higher as the remainder
of 2005 unfolds," stated Lawrence A. Collett, Cass chief executive officer and
chairman. "Our results are gratifying on many levels. I commend our team for its
sense of purpose, clarity of vision and proficiency in executing our strategy
for growth."

      Payment and processing fees increased 20% or $1,503,000 in the 2005 third
quarter compared to 2004, as transportation invoices were up 12% and dollar
volume rose 23% due to new business and heightened activity from existing
accounts. Payment and processing fees also increased as utility invoices
processed were up 9%, and include the results from the company's telecom group,
which was acquired in August 2004.

      "Understandably, we are delighted with the consistent, strong growth we
are witnessing in our information processing operations," Collett added.


                                       5


      Additionally, the company's Government e-Management Solutions, Inc. (GEMS)
subsidiary reported a 16% or $225,000 increase in software sale revenues as the
national market GEMS serves responded favorably to its recently enhanced product
line.

      Net investment income increased 21% or $1,462,000 due mainly to growth in
funds generated from processing activities and to the rise in prevailing
interest rates.

      Total operating expenses increased 9% or $1,265,000 largely as a result of
the telecom acquisition as well as expenses tied to the growth in payments
processed.

      Finally, the company's effective income tax rate rose from 27% to 34% for
the period, due primarily to a decrease in the lower relative effect of
tax-exempt securities held during the quarter.

Nine-Month 2005 Results

      For the nine-month period ended September 30, 2005, the company earned
$1.50 per fully-diluted share, a 52% increase from the $.99 per fully-diluted
share reported for the same period in 2004. Net income was $8,444,000, 53%
higher than the $5,520,000 earned in the first nine months of 2004. Total
revenues rose $9,071,000 or 19% for the first nine months of 2005 compared to
2004 due to increased processing volumes, fee revenues, software sales and
investment income. Operating expenses were up 10% or $4,010,000 in the
nine-month year-over-year period, primarily due to the telecom acquisition.


                                       6


                      Selected Consolidated Financial Data

      The following table presents selected unaudited consolidated financial
data (in thousands, except per share data) for the periods ended September 30,
2005 and 2004:

Quarter Quarter Nine Months Nine Months Ended Ended Ended Ended 9/30/05 9/30/04 9/30/05 9/30/04 Transportation Invoice Volume 6,846 6,104 19,911 17,454 Transportation Dollar Volume $ 3,111,175 $ 2,535,799 $ 8,548,554 $ 7,173,613 Utility Transaction Volume 1,419 1,304 4,225 3,874 Utility Dollar Volume $ 1,148,449 $ 985,369 $ 3,166,864 $ 2,815,462 Payment and Processing Fees $ 9,157 $ 7,654 $ 26,486 $ 22,873 Software Revenue 1,658 1,433 5,258 3,746 Net Investment Income 8,359 6,897 23,458 19,594 Gain on Sales of Debt Securities -- -- 547 441 Other 563 519 1,651 1,675 ----------- ----------- ----------- ----------- Total Revenues $ 19,737 $ 16,503 $ 57,400 $ 48,329 Salaries and Benefits $ 10,734 $ 9,579 $ 31,688 $ 28,037 Occupancy 562 460 1,633 1,354 Equipment 834 877 2,501 2,888 Other 2,931 2,880 8,779 8,312 ----------- ----------- ----------- ----------- Total Operating Expenses $ 15,061 $ 13,796 $ 44,601 $ 40,591 Income before Income Taxes $ 4,676 $ 2,707 $ 12,799 $ 7,738 Provision for Income Taxes $ 1,583 $ 734 $ 4,355 $ 2,218 Net Income $ 3,093 $ 1,973 $ 8,444 $ 5,520 Average Earning Assets $ 700,442 $ 665,105 $ 682,092 $ 630,719 Net Interest Margin 4.98% 4.42% 4.85% 4.44% Allowance for Loan Losses to Loans 1.20% 1.21% 1.20% 1.21% Non-performing Loans to Total Loans .22% .27% .22% .27% Net Loan Charge-offs to Loans -- -- .08% -- Provision for Loan Losses $ 225 $ 150 $ 625 $ 500 Non-performing Loans $ 1,134 $ 1,289 $ 1,134 $ 1,289 Basic Earnings per Share $ .56 $ .35 $ 1.53 $ 1.00 Diluted Earnings per Share $ .55 $ .35 $ 1.50 $ .99
7 About Cass Information Systems Cass has been a leading provider of payables services and information support systems to companies throughout North America since 1956. The company pays over $14 billion annually in freight, utility, and telecom invoices on behalf of its customers from processing centers in St. Louis, Mo., Columbus, Ohio, Boston, Mass. and Greenville, S.C. The support of its bank subsidiary, Cass Commercial Bank, founded in 1906, makes Cass Information Systems unique in the industry. Note to Investors Certain matters set forth in this news release may contain forward-looking statements that are provided to assist in the understanding of anticipated future financial performance. However, such performance involves risks and uncertainties that may cause actual results to differ materially from those in such statements. For a discussion of certain factors that may cause such forward-looking statements to differ materially from the company's actual results, see the company's reports filed from time to time with the Securities and Exchange Commission including the company's annual report on Form 10-K for the year ended December 31, 2004. 8